ABSTRACT AP-1-like transcription factors play evolutionarily conserved roles as redox sensors in eukaryotic oxidative stress responses. In this study, we aimed to elucidate the regulatory mechanism of an atypical yeast AP-1-like protein, Yap1, in the stress response and virulence of Cryptococcus neoformans. YAP1 expression was induced and involved not only by oxidative stresses, such as H2O2 and diamide, but also by other environmental stresses, such as osmotic and membrane-destabilizing stresses. Yap1 was distributed throughout both the cytoplasm and the nucleus under basal conditions and more enriched within the nucleus in response to diamide but not to other stresses. Deletion of the C-terminal cysteine-rich domain (c-CRD), where the nuc...
SummarySaccharomyces cerevisiae responds to elevated levels of hydrogen peroxide in its environment ...
Fungal survival in a mammalian host requires the coordinated expression and downregulation of a larg...
ABSTRACT Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this en...
Yeast adaptation to stress has been extensively studied. It involves large reprogramming of genome e...
Host defenses expose fungal pathogens to oxidants and antimicrobial chemicals. The fungal cell emplo...
Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process,...
The yeast Saccharomyces cerevisiae transcription factor Yap1 mediates an adaptive response to oxidat...
<div><p><i>Talaromyces marneffei</i>, formerly <i>Penicillium marneffei</i>, is a thermally dimorphi...
AbstractTo define the essential amino acid residues of Yap1 in stress response, we generated yap1 mu...
AbstractTowards elucidating the function of Yap2, which remains unclear, we have taken advantage of ...
International audienceFlavohemoglobins are the main detoxifiers of nitric oxide (NO) in bacteria and...
ABSTRACT Cryptococcus neoformans is one of the few environmental fungi that can survive within a mam...
Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the nex...
Post-PrintIn the budding yeast Saccharomyces cerevisiae arsenic detoxification involves the activat...
AP-1 proteins are transcription factors (TFs) that belong to the basic leucine zipper family, one of...
SummarySaccharomyces cerevisiae responds to elevated levels of hydrogen peroxide in its environment ...
Fungal survival in a mammalian host requires the coordinated expression and downregulation of a larg...
ABSTRACT Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this en...
Yeast adaptation to stress has been extensively studied. It involves large reprogramming of genome e...
Host defenses expose fungal pathogens to oxidants and antimicrobial chemicals. The fungal cell emplo...
Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process,...
The yeast Saccharomyces cerevisiae transcription factor Yap1 mediates an adaptive response to oxidat...
<div><p><i>Talaromyces marneffei</i>, formerly <i>Penicillium marneffei</i>, is a thermally dimorphi...
AbstractTo define the essential amino acid residues of Yap1 in stress response, we generated yap1 mu...
AbstractTowards elucidating the function of Yap2, which remains unclear, we have taken advantage of ...
International audienceFlavohemoglobins are the main detoxifiers of nitric oxide (NO) in bacteria and...
ABSTRACT Cryptococcus neoformans is one of the few environmental fungi that can survive within a mam...
Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the nex...
Post-PrintIn the budding yeast Saccharomyces cerevisiae arsenic detoxification involves the activat...
AP-1 proteins are transcription factors (TFs) that belong to the basic leucine zipper family, one of...
SummarySaccharomyces cerevisiae responds to elevated levels of hydrogen peroxide in its environment ...
Fungal survival in a mammalian host requires the coordinated expression and downregulation of a larg...
ABSTRACT Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this en...